Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …

Claudins are cell–cell adhesion molecules located at the tight junctions (TJs) between cells
in epithelial cell sheets. The claudin family in mammals consists of 27 four-transmembrane …

Tight junctions are cell-adhesion complexes that seal tissues and are involved in cell
polarity and signaling. Supra-molecular assembly and positioning of tight junctions as …

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a
selectively permeable barrier that supports nutrient absorption and waste secretion while …

Abstract The claudin18. 2 (CLDN18. 2) protein, an isoform of claudin18, a member of the
tight junction protein family, is a highly selective biomarker with limited expression in normal …

Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …