Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a family of RNA-binding
proteins. The complexity and diversity associated with the hnRNPs render them …

Members of the FET protein family, consisting of FUS, EWSR1, and TAF15, bind to RNA and
contribute to the control of transcription, RNA processing, and the cytoplasmic fates of …

Translocated in liposarcoma, Ewing's sarcoma and TATA-binding protein-associated factor
15 constitute an interesting and important family of proteins known as the TET proteins. The …

Sarcomas account for less than 10% of all human malignancies that are believed to
originate from as yet poorly defined mesenchymal progenitor cells. They constitute some of …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Tumor-associated chromosomal translocations lead to the formation of chimeric fusions
between the EWS gene and one of five different ETS transcription factors in Ewing's family …

The arrest of differentiation is a feature of both chronic myelogenous leukemia cells in
myeloid blast crisis and myeloid precursors that ectopically express the p210BCR-ABL …

Subcellular mislocalization and aggregation of the human FUS protein occurs in neurons of
patients with subtypes of amyotrophic lateral sclerosis and frontotemporal dementia. FUS is …

OTUB (otubain) 1 is a human deubiquitinating enzyme that is implicated in mediating
lymphocyte antigen responsiveness, but whose molecular function is generally not well …

In a BCR/ABL-expressing myeloid precursor cell line, p53 levels were markedly
downmodulated. Expression of MDM2, the negative regulator of p53, was upregulated in a …