The number of primordial follicles in the ovarian reserve is an important determinant of the
length of the ovarian lifespan, and therefore the fertility of an individual. This reserve …

The female germline comprises a reserve population of primordial (non-growing) follicles
containing diplotene oocytes arrested in the first meiotic prophase. By convention, the …

We sequenced more than 52,500 single cells from embryonic day 11.5 (E11. 5)
postembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

Accurate determination of estrus is essentially required for efficient reproduction
management of farm animals. Buffalo is a shy breeder and does not manifest overt signs of …

The female reproductive lifespan is largely determined by the size of primordial follicle pool,
which is established following germ cell cyst breakdown around birth. Almost two-third of …

Abstract Development of the ovary or testis is required to establish reproductive
competence. Gonad development relies on key cell fate decisions that occur early in …

Human granulosa cells in different stages are essential for maintaining normal ovarian
function, and granulosa cell defect is the main cause of ovarian dysfunction. To address this …

The follicle is the functional unit of the mammalian ovary and serves as a tightly controlled
microenvironment where granulosa cells nurture the growth and maturation of the oocyte …

In vitro systems capable of reconstituting the process of mouse oogenesis are now being
established to help develop further understanding of the mechanisms underlying …