Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

Malaria poses a severe public health risk and a significant economic burden in disease-
endemic countries. One of the most severe issues in malaria control is the development of …

Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

The increase in antibiotic resistance due to various factors has encouraged the look for
novel compounds which are active against multidrug-resistant pathogens. In this framework …

Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

The present study was carried out in an attempt to synthesize a new class of antimicrobial
and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10 …

A new series of N–substituted 2–pyrazolines 9a–f, 10a–f, 11a–f, 12a–f and 13a–f were
obtained from the cyclocondensation reaction of [(7–chloroquinolin–4–yl) amino] chalcones …

The design and synthesis of a new series of indole-chalcone linked 1, 2, 3-triazole hybrids
via Cu (Ι)-catalyzed azide-alkyne cycloaddition is reported. All the compounds (2, 4a–4e and …