Wound healing is a localized process which involves inflammation, wound cell migration
and mitosis, neovascularization, and regeneration of the extracellular matrix. Recent data …

The rationale to inhibit the epidermal growth factor receptor (EGFR) tyrosine kinase family as
an approach to cancer chemotherapy has continued to grow stronger over the last 10 years …

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very
closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian …

The epidermal growth factor (EGF) receptor is a tyrosine-specific protein kinase with
autophosphorylating activity1–4. A 300 amino acid-long region of the receptor's cytoplasmic …

TRANSCRIPTION of the proto-oncogene c-fos is stimulated rapidly and transiently by serum
growth factors and mitogens1. Critical for this response is the serum-response element …

Epidermal growth factor (EGF) receptor monomers and noncovalently associated dimers
were isolated by sucrose density gradient centrifugation, and their respective binding and …

We have isolated a soluble 35-kDa protein from A-431 cells that in the presence of calcium
can serve as a substrate for the epidermal growth factor (EGF)-receptor/kinase. The …

Receptor dimerization is critical for signaling by the epidermal growth factor receptor (EGFR)
tyrosine kinase. This occurs after binding of the receptor's extracellular domain by ligand or …

My own efforts in this area of research over the past thirty years have been directed toward
the understanding, on a biochemical level, of two biological observations, both initially made …

Epidermal growth factor (EGF) binds with high affinity and specificity to a single site on the
external domain of its transmembrane receptor to activate the tyrosine protein kinase activity …