Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

This tutorial review covers the recent advances made in the study of gold complexes
containing N-heterocyclic carbene ligands with biological properties. The great stability …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Highlights•Metal-NHC complexes have their metal centers stabilized under physiological
conditions and can exhibit anticancer activity.•Metal-NHC complexes having new …

Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

Mammalian thioredoxin reductase (TrxR) enzymes are homodimeric flavin proteins sharing
a unique yet essential selenocysteine residue at their C‐terminus. TrxRs, together with their …

The thioredoxin system is highly conserved system found in all living cells and comprises
NADPH, thioredoxin, and thioredoxin reductase. This system plays a critical role in …

The advent of the clinically approved drug cisplatin started a new era in the design of
metallodrugs for cancer chemotherapy. However, to date, there has not been much success …