Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …

Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for
more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is …

The present study is on the development of dialkyl 4-(benzo [d][1, 3] dioxol-6-yl)-1, 4-dihydro-
2, 6-dimethyl-1-substituted pyridine-3, 5-dicarboxylate derivatives as isosteric analogues of …

Background: Nipecotic acid is considered to be one of the most potent inhibitors of neuronal
and glial γ-aminobutyric acid (GABA) uptake in vitro. However, nipecotic acid does not …

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy with about 30% of
patients developing pharmacoresistance. These patients continue to suffer from seizures …

In drug discovery and development, the kinetic study of active metabolites plays an
important role, helping to define the time course of the drug in the body and its activity or …

Abstract A series of (E)-3-(benzo [d][1, 3] dioxol-5-ylmethylene) pyrrolidin-2-one derivatives
were designed, synthesized, and evaluated for their anticonvulsant activities. In the …

Two series of 1-alkyl-4-(4H-1, 2, 4-triazol-4-yl) piperidines and 1-alkyl-4-(2H-1, 2, 4-triazol-3-
one-4-yl) piperidines were synthesized and their anticonvulsant and antibacterial activities …

Refractive indices, n D, of two binary liquid systems of methyl acetate (MAc)+
methylethanolamine (MEA), and MAc+ dimethylethanolamine (DMEA) each at twenty-one …

Epilepsy is one of the most common, chronic and serious neurological disorder, affecting
million people worldwide. This brain disorder is characterised by recurrent spontaneous …