This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

Metabolic reprogramming in cancer and immune cells occurs to support their increasing
energy needs in biological tissues. Here we propose Single Cell Spatially resolved …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically
aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain …

The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and
targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

Class-switch recombination (CSR) is a DNA recombination process that replaces the
immunoglobulin (Ig) constant region for the isotype that can best protect against the …

Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …