Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Optical forces, generally arising from changes of field gradients or linear momentum carried
by photons, form the basis for optical trapping and manipulation. Advances in optical forces …

Optical tweezers are tools made of light that enable contactless pushing, trapping, and
manipulation of objects, ranging from atoms to space light sails. Since the pioneering work …

Optical manipulation has achieved great success in the fields of biology, micro/nano robotics
and physical sciences in the past few decades. To date, the optical manipulation is still …

The invention of optical tweezers more than three decades ago has opened new avenues in
the study of the mechanical properties of biological molecules and cells. Quantitative force …

Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

Omecamtiv mecarbil (OM) is a positive cardiac inotrope in phase-3 clinical trials for
treatment of heart failure. Although initially described as a direct myosin activator …

Single molecule force spectroscopy methods, such as optical and magnetic tweezers and
atomic force microscopy, have opened up the possibility to study biological processes …

The last 15 years saw a dramatic increase in the number of published papers exposing
research related to the concept of protein disorder and a concomitant increase in the …

A principal goal of molecular biophysics is to show how protein structural transitions explain
physiology. We have developed a strategic tool, transient time-resolved FRET [(TR) 2FRET] …