Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases

M Amanollahi, M Jameie, A Heidari, N Rezaei - Molecular neurobiology, 2023 - Springer
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function

KK Kummer, M Zeidler, T Kalpachidou, M Kress - Cytokine, 2021 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

[HTML][HTML] The pro-and anti-inflammatory properties of the cytokine interleukin-6

J Scheller, A Chalaris, D Schmidt-Arras… - Biochimica et Biophysica …, 2011 - Elsevier
Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also
in the regulation of metabolic, regenerative, and neural processes. In classic signaling …

The role of markers of inflammation in traumatic brain injury

T Woodcock, MC Morganti-Kossmann - Frontiers in neurology, 2013 - frontiersin.org
Within minutes of a traumatic impact, a robust inflammatory response is elicited in the injured
brain. The complexity of this post-traumatic squeal involves a cellular component …

Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone

Y Shigemoto-Mogami, K Hoshikawa… - Journal of …, 2014 - Soc Neuroscience
Although microglia have long been considered as brain resident immune cells, increasing
evidence suggests that they also have physiological roles in the development of the normal …

Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches

PS Sung, PY Lin, CH Liu, HC Su, KJ Tsai - International journal of …, 2020 - mdpi.com
In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

The role of inflammatory cytokines as key modulators of neurogenesis

A Borsini, PA Zunszain, S Thuret, CM Pariante - Trends in neurosciences, 2015 - cell.com
Neurogenesis is an important process in the regulation of brain function and behaviour,
highly active in early development and continuing throughout life. Recent studies have …

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

SG Fillman, N Cloonan, VS Catts, LC Miller… - Molecular …, 2013 - nature.com
Upregulation of the immune response may be involved in the pathogenesis of schizophrenia
with changes occurring in both peripheral blood and brain tissue. To date, microarray …