Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors,
presenting significant challenges for treatment due to their invasive nature and localization …

Vaccines are essential tools to prevent infection and control transmission of infectious
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …

Annually, seasonal influenza is responsible for millions of infections and hundreds of
thousands of deaths. The current method for managing influenza is vaccination using a …

ABSTRACT Clade 2.3. 4.4 H5Nx subtype avian influenza viruses (AIVs) have circulated in
poultry and wild birds worldwide. Recently, an increasing number of H5Nx human infection …

The influenza neuraminidase (NA) is a promising target for next-generation vaccines.
Protection induced by vaccination with the computationally optimized broadly reactive NA …

To highlight the particular needs with respect to modeling the unique and complex
organization of the human brain structure, we reviewed the state-of-the-art in devising brain …

We have developed a new universal influenza B vaccination strategy based on inactivated
influenza B viruses displaying mosaic hemagglutinins (mHAs). Recombinant mHA viruses …

Abstract Narcolepsy type 1 (NT1), characterized by the loss of hypocretin/orexin (HCRT)
production in the lateral hypothalamus, has been linked to Pandemrix vaccination during the …

Animal models are essential for studying disease pathogenesis and to test the efficacy and
safety of new vaccines and therapeutics. For most diseases, there is no single model that …

Vaccination remains the sole effective strategy for combating Japanese encephalitis (JE).
Both inactivated and live attenuated vaccines exhibit robust immunogenicity. However, the …