Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Behavioral and psychological symptoms of dementia (BPSD), also known as
neuropsychiatric symptoms, represent a heterogeneous group of non-cognitive symptoms …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the
brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on …

The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …

Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …