Mouse genetic engineering has revolutionized our understanding of the molecular and
genetic basis of heart development and disease. This technology involves conditional tissue …

Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the
synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity …

Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and
behaviors modulated by 5-HT. Several cascade factors are expressed throughout the …

Ca2+/calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity
and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in …

The development, function, and pathology of the brain depend on interactions of neurons
and different types of glial cells, namely astrocytes, oligodendrocytes, microglia, and …

Gene targeting in ES cells is extensively used to generate designed mouse mutants and to
study gene function in vivo. Knockout mice that harbor a null allele in their germline provide …

The CreER/LoxP system is widely accepted to track neural lineages and study gene
functions upon tamoxifen (TAM) administration. We have observed that prenatal TAM …

Adult neurogenesis is a tightly regulated process continuously taking place in the central
nervous system of most mammalian species. In neuroscience research, transgenic animals …

N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent
connections in the developing and adult brain. Impaired NMDAR signalling through genetic …

The endocannabinoid (eCB) system possesses neuromodulatory functions by influencing
the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and …