Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with
cancer stem cells (CSC) to maintain stemness. We recently identified cluster of …

The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …

Over the last few decades, study of cancer in mouse models has gained popularity.
Sophisticated genetic manipulation technologies and commercialization of these murine …

Resistance to treatment is one of the biggest challenges in combating head and neck
squamous cell carcinoma (HNSCC). The concept of resistance, however, is often viewed as …

Despite advanced clinical and translational oncology research, mortality rates are still
increasing worldwide. Recently, a class of non-coding RNAs (ncRNAs), such as microRNAs …

The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In
medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in Hh pathway …

Hedgehog (Hh) is first described as a genetic mutation that has “spiked” phenotype in the
cuticles of Drosophila in later 1970s. Since then, Hh signaling has been implicated in …

The limitations of cancer cell lines have led to the development of direct patient-derived
xenograft models. However, the interplay between the implanted human cancer cells and …