The invention of optical tweezers more than three decades ago has opened new avenues in
the study of the mechanical properties of biological molecules and cells. Quantitative force …

Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

Significance: Optical trapping is a technique capable of applying minute forces that has
been applied to studies spanning single molecules up to microorganisms. Aim: The goal of …

The accurate study of cellular microenvironments is limited by the lack of technologies that
can manipulate cells in 3D at a sufficiently small length scale. The ability to build and …

Optical trapping with plasmonic double nanohole (DNH) apertures has proven to be an
efficient method for trapping sub-50 nm particles due to their suppressed plasmonic heating …

The mechanical phenotype of a cell determines its ability to deform under force and is
therefore relevant to cellular functions that require changes in cell shape, such as migration …

This note reports observations of the change of stiffness of human mesenchymal stem cells
(hMSCs) with the progress of cell death as measured by AFM. hMSC with impaired …

Optical manipulation is a technology that enables accurate manipulation of micro-robots in
fluidic environment. Optical micro-robots, which can be used as micro-tools to perform …

Cell dielectric properties, a type of intrinsic property of cells, can be used as
electrophysiological biomarkers that offer a label-free way to characterize cell phenotypes …

Although it has been established that cellular stiffness can change as a stem cell
differentiates, the precise relationship between cell mechanics and other phenotypic …