We propose an updated version of the Interaction of Person-Affect-Cognition-Execution (I-
PACE) model, which we argue to be valid for several types of addictive behaviors, such as …

The feeding process is required for basic life, influenced by environment cues and tightly
regulated according to demands of the internal milieu by regulatory brain circuits. Although …

Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in developing …

Objectives: Outline the various presentations of substance use disorders. Identify etiologies
and pathophysiology of substance use disorders Describe various treatment options for …

Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance
leading to physiological and psychological alterations and often changes in cognitive and …

Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health
and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously …

In this review, we present the latest advances in the field of multi-target-directed ligand
(MTDL) design for the treatment of various complex pathologies of multifactorial origin. In …

Introduction Drug addiction is associated with disruption of a multitude of biomarkers in
various brain regions, particularly in the reward centre. The most pronounced are …

It is well recognized throughout the history that religiosity, spirituality and the meditation
practice have significant effects to the physical and mental health. Hence, this paper …

Drug addiction is considered a chronic disorder affecting the individual's life, his/her family
and society. Up till now the treatment of drug addiction is considered a problematic issue …