Spirocyclic motifs are emerging privileged structures for drug discovery. They are also
omnipresent in the natural products domain. However, until today, no attempt to analyze the …

Covering: 2002. Previous review: Nat. Prod. Rep., 2003, 20, 1 This review covers the
literature published in 2002 for marine natural products, with 579 citations (413 for the …

Pinnatoxins belong to an emerging class of potent marine toxins of the cyclic imine group.
Detailed studies of their biological effects have been impeded by unavailability of the …

Background: The spirocyclic compounds have always aroused a great interest because this
motif is present as structural core in a number of natural products and bioactive compounds …

Covering: January to December, 2002. Previous review: Nat. Prod. Rep., 2002, 19, 650 This
review covers the isolation, structural determination, synthesis and chemical and …

The ABD-ring of phomactin A was synthesized using an intramolecular formal oxa-[3+ 3]
cycloaddion of an α, β-unsaturated iminium salt tethered to a 1, 3-diketone. This represents …

Three norsesquiterpenoids, pathyspirolactones A (1) and B (2), and napalilactone (3),
featuring a γ-spirolactone moiety, were isolated from the cultured octocoral Paralemnalia …

An enantioselective synthesis of the bis-spiroacetal fragment of spirolides B and D is
reported. The carbon framework was constructed via Barbier reaction of dihydropyran 3 with …

The enantioselective synthesis of the bis-spiroacetal fragment of the shellfish toxins,
spirolides B 1 and D 2, is reported. The carbon framework was constructed via a Barbier …

The Brazilian marine biodiversity represents a unique, yet underexplored resource of
biologically active compounds. This review provides an analysis of the development of …