Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicingregulatory elements of specific cancer genes or from changes in the …

Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate
ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered …

The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the
self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor …

Understanding interactions occurring at the interface between nanoparticles and biological
components is an urgent challenge in nanomedicine due to their effect on the biological fate …

Colorectal cancer is one of the most common malignant tumors worldwide. A model of
cancer development involving cancer stem cells has been put forward because it provides a …

Nanoparticles exposed to biological fluids such as blood, quickly interact with their
surrounding milieu resulting in a biological coating that results in large part as a function of …

Colorectal cancer remains one of the most common and lethal malignancies worldwide
despite the use of various therapeutic strategies. A better understanding of the mechanisms …

Alternative RNA splicing is an essential process to yield proteomic diversity in eukaryotic
cells, and aberrant splicing is often associated with numerous human diseases and cancers …

Ser/Arg-rich (SR) proteins are RNA-binding proteins known as constitutive and alternative
splicing (AS) regulators that regulate multiple aspects of the gene expression program …

Splicing of premRNA is an essential part of eukaryotic gene expression. Serine/arginine
rich (SR) proteins are highly conserved RNAbinding proteins present in all metazoans and …