Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …

PURPOSE To increase awareness, outline strategies, and offer guidance on the
recommended management of immune-related adverse events (irAEs) in patients treated …

Background T cell mediated hyperinflammatory responses such as cytokine release
syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome comprising familial/genetic HLH (FHL) and secondary HLH. In the HLH-94 study …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Background Hemophagocytic lymphohistiocytosis is a cytokine-driven inflammatory
syndrome that is associated with substantial morbidity and mortality. Overall survival in adult …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

Immune effector cell (IEC) therapies offer durable and sustained remissions in significant
numbers of patients with hematological cancers. While these unique immunotherapies have …

The article focuses on cytokine storm syndrome which is a diverse set of conditions unified
by a clinical phenotype of systemic inflammation, multi-organ failure and hyperferritinemia …