Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson's disease and is also linked to its idiopathic form. LRRK2 has been proposed to …

Human genetic studies implicate LRRK2 and RAB7L1 in susceptibility to Parkinson disease
(PD). These two genes function in the same pathway, as knockout of Rab7L1 results in …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of
familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD …

Mutations in the LRRK2 gene represent the most common genetic cause of late onset
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …

The leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of
autosomal-dominant Parkinson disease (PD). Mitochondrial dysfunction represents a critical …

Parkinson's disease, like many common age-related conditions, is now recognized to have a
substantial genetic component. Here, I discuss how mutations in a large complex gene …

LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients, but still little is understood about how it is regulated or …

LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine …