Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

An important unresolved issue in microbial secondary metabolite production is the
abundance of biosynthetic gene clusters that are not expressed under typical laboratory …

Abstract Background The Streptomyces albus J1074 strain is one of the most widely used
chassis for the heterologous production of bioactive natural products. The fast growth and an …

Covering: up to May 2010 This review (with 214 references cited) is devoted to
moenomycins, the only known group of antibiotics that directly inhibit bacterial …

As bacteria and fungi have been found to contain genes encoding enzymes that synthesize
a plethora of potential secondary metabolites, interest has grown in the activation of these …

Due to the worldwide prevalence of multidrug-resistant pathogens and high incidence of
diseases such as cancer, there is an urgent need for the discovery and development of new …

Streptomyces spp. are robust producers of medicinally-, industrially-and agriculturally-
important small molecules. Increased resistance to antibacterial agents and the lack of new …

Covering up to December 2013 Oligosaccharide natural products target a wide spectrum of
biological processes including disruption of cell wall biosynthesis, interference of bacterial …

Heterologous production of recombinant proteins is gaining increasing interest in
biotechnology with respect to productivity, scalability, and wide applicability. The members …