The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only
by providing structural support, but also by facilitating force transmission, and by transducing …

Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …

Collagen production in the adult heart is thought to be regulated by the fibroblast, although
cardiomyocytes and endothelial cells also express multiple collagen mRNAs. Molecular …

The endoplasmic reticulum (ER) comprises a network of tubules and vesicles that
constitutes the largest organelle of the eukaryotic cell. Being the location where most …

Cell communication is needed for organ function and stress responses, especially in the
heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the …

The extracellular matrix (ECM) provides structural support and a microenvironmentfor
soluble extracellular molecules. ECM is comprised of numerous proteins which can be …

OBJECTIVE To assess the effects of empagliflozin, a selective sodium–glucose
cotransporter 2 (SGLT2) inhibitor, on broad biological systems through proteomics …

The survival and growth of fish are significantly impacted by a hypoxic environment (low
dissolved oxygen). In this study, we compared tissue structure, physiological changes, and …