Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Background: Mechanical stress on the heart, such as high blood pressure, initiates
inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of …

Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

Patients with type 2 diabetes mellitus have an increased risk for the development of cardiac
and other vascular events, heart failure (HF), and decline in renal function. After several …

The life expectancy of the global population has increased. Aging is a natural physiological
process that poses major challenges in an increasingly long-lived and frail population …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Objective Insulin resistance, hyperandrogenism, sympathetic dysfunction and chronic low‐
grade inflammation may act together in a vicious cycle in the pathophysiology of PCOS …