The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …

The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …

Pregnane x receptor (PXR) as a nuclear receptor is well-established in drug metabolism,
however, it has pleiotropic functions in regulating inflammatory responses, glucose …

Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally,
causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to …

The transcription suppressor factor FBI-1 (the factor that binds to inducer of short transcripts-
1) is an important regulator of hepatocellular carcinoma (HCC). In this work, the results …

Abstract Design and development of efficient drug delivery technologies that impart site-
specificity is the need of the hour for the effective treatment of lung cancer. The emergence …

Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies,
including cancer. In breast cancer, the link is especially strong due to interactions between …

Allopregnanolone (3α-THP) has been one of the most studied progesterone metabolites for
decades. 3α-THP and its synthetic analogs have been evaluated as therapeutic agents for …

The incidence of nonalcoholic fatty liver disease (NAFLD) has been rising worldwide in
parallel with diabetes and metabolic syndrome. NAFLD refers to a spectrum of liver …

This review explores the likely clinical impact of Pregnane X Receptor (PXR) activation by
vitamin K on human health. PXR, initially recognized as a master regulator of xenobiotic …