Adverse Food Reactions: Physiological and Ecological Perspectives

LL Korn, VI Kutyavin, ND Bachtel… - Annual Review of …, 2024 - annualreviews.org
While food is essential for survival, it can also cause a variety of harmful effects, ranging from
intolerance to specific nutrients to celiac disease and food allergies. In addition to nutrients …

The changing metabolic landscape of bile acids–keys to metabolism and immune regulation

I Mohanty, C Allaband, H Mannochio-Russo… - Nature reviews …, 2024 - nature.com
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

[HTML][HTML] The underappreciated diversity of bile acid modifications

I Mohanty, H Mannochio-Russo, JV Schweer… - Cell, 2024 - cell.com
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial
metabolism remains incompletely characterized. To address this knowledge gap, we …

[HTML][HTML] Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway

Q Nie, X Luo, K Wang, Y Ding, S Jia, Q Zhao, M Li… - Cell, 2024 - cell.com
The gut microbiota has been found to play an important role in the progression of metabolic
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …

Shifts in the functional capacity and metabolite composition of the gut microbiome during recovery from enteric infection

ZA Hansen, AL Schilmiller, DV Guzior… - Frontiers in Cellular …, 2024 - frontiersin.org
While enteric pathogens have been widely studied for their roles in causing foodborne
infection, their impacts on the gut microbial community have yet to be fully characterized …

[HTML][HTML] Selective lipid recruitment by an archaeal DPANN symbiont from its host

S Ding, JN Hamm, NJ Bale… - Nature …, 2024 - nature.com
Abstract The symbiont Ca. Nanohaloarchaeum antarcticus is obligately dependent on its
host Halorubrum lacusprofundi for lipids and other metabolites due to its lack of certain …

Emerging tools and best practices for studying gut microbial community metabolism

C Noecker, PJ Turnbaugh - Nature Metabolism, 2024 - nature.com
The human gut microbiome vastly extends the set of metabolic reactions catalysed by our
own cells, with far-reaching consequences for host health and disease. However, our …

Machine learning–enhanced molecular network reveals global exposure to hundreds of unknown PFAS

X Wang, N Yu, Z Jiao, L Li, H Yu, S Wei - Science Advances, 2024 - science.org
Unknown forever chemicals like per-and polyfluoroalkyl substances (PFASs) are difficult to
identify. Current platforms designed for metabolites and natural products cannot capture the …

The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms

MW Van Goethem, R Marasco, PY Hong… - Microbial …, 2024 - Wiley Online Library
In the relentless battle for human health, the proliferation of antibiotic‐resistant bacteria has
emerged as an impending catastrophe of unprecedented magnitude, potentially driving …

Our extended microbiome: The human-relevant metabolites and biology of fermented foods

EB Caffrey, JL Sonnenburg, S Devkota - Cell Metabolism, 2024 - cell.com
One of the key modes of microbial metabolism occurring in the gut microbiome is
fermentation. This energy-yielding process transforms common macromolecules like …