Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Chromatin regulators play a broad role in regulating gene expression and, when gone awry,
can lead to cancer. Here, we demonstrate that ablation of the histone demethylase LSD1 in …

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key
stabilizing factors for the maintenance of replication fork integrity following replication stress …

How chromatin shapes pathways that promote genome–epigenome integrity in response to
DNA damage is an issue of crucial importance. We report that human bromodomain (BRD) …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

Transposable elements or transposons are major players in genetic variability and genome
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA
damage signaling and repair within chromatin. In this study, we report the identification of …