Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

YB Tan, LS Lello, X Liu, YS Law, C Kang… - Nucleic acids …, 2022 - academic.oup.com
Abstract Alphaviruses such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis
virus (SINV), and Venezuelan equine encephalitis virus (VEEV) are mosquito-borne …

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

MM Varikkodan, F Kunnathodi, S Azmi, TY Wu - Vaccines, 2023 - mdpi.com
Chikungunya virus (CHIKV) is an infectious agent spread by mosquitos, that has
engendered endemic or epidemic outbreaks of Chikungunya fever (CHIKF) in Africa, South …

Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity

P Leung, AA Eltahla, AR Lloyd, RA Bull, F Luciani - Virus research, 2017 - Elsevier
With the advent of affordable deep sequencing technologies, detection of low frequency
variants within genetically diverse viral populations can now be achieved with …

The bridges and blockades to evolutionary convergence on the road to predicting chikungunya virus evolution

M Vignuzzi, S Higgs - Annual Review of Virology, 2017 - annualreviews.org
Chikungunya virus, first isolated in the 1950s, has since reemerged to cause several
epidemics and millions of infections throughout the world. What was once blurred and …

Optimization of commercially available Zika virus antibodies for use in a laboratory‐developed immunohistochemical assay

BC Bollweg, L Silva‐Flannery… - The Journal of …, 2018 - Wiley Online Library
Zika virus (ZIKV) infection during pregnancy can cause adverse fetal outcomes and severe
irreversible congenital birth defects including microcephaly. Immunohistochemistry (IHC) is …

[HTML][HTML] Virus chikungunya: Características virales y evolución genética

G Cervantes-Acosta, H Sanjuán-Vergara - Revista Salud Uninorte, 2016 - scielo.org.co
El virus chikungunya pertenece al género Alphavirus, de la familia de los Togaviridae. Es
transmitido por artrópodos, en particular por la picada de especies de mosquitos, tales …

The putative roles and functions of indel, repetition and duplication events in alphavirus non-structural protein 3 hypervariable domain (nsP3 HVD) in evolution …

N Abdullah, N Ahemad, K Aliazis, JE Khairat, TC Lee… - Viruses, 2021 - mdpi.com
Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be
crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated …

COVTree: Coevolution in OVerlapped sequences by Tree analysis server

E Teppa, DJ Zea, F Oteri, A Carbone - Nucleic Acids Research, 2020 - academic.oup.com
Overlapping genes are commonplace in viruses and play an important role in their function
and evolution. For these genes, molecular coevolution may be seen as a mechanism to …

Chikungunya virus: Molecular epidemiology of nonstructural proteins in Pakistan

N Badar, A Ikram, M Salman, MM Alam, M Umair… - Plos one, 2021 - journals.plos.org
Chikungunya virus (CHIKV) is considered a public health problem due to its rapid spread
and high morbidity. In 2016–2017 an outbreak of CHIKV was occurred in Pakistan but the …

[PDF][PDF] Bioinformatics and statistical methods to study the evolution of primary HCV infection

P Leung - 2018 - unsworks.unsw.edu.au
HCV is a rapidly mutating RNA virus, which affects 170 million people globally. The genome
mutates rapidly to generate many variants (quasispecies) in every infected individual. Yet …