Regulation of tumour necrosis factor signalling: live or let die
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …
Signalling pathways of the TNF superfamily: a double-edged sword
BB Aggarwal - Nature reviews immunology, 2003 - nature.com
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
J Zhang, B Zhou, R Sun, Y Ai, K Cheng, F Li, B Wang… - Cell research, 2021 - nature.com
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among
which the function of GSDMC has not been clearly described. Herein, we demonstrate that …
which the function of GSDMC has not been clearly described. Herein, we demonstrate that …
Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …
[HTML][HTML] The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
T Tenev, K Bianchi, M Darding, M Broemer, C Langlais… - Molecular cell, 2011 - cell.com
A better understanding of the mechanisms through which anticancer drugs exert their effects
is essential to improve combination therapies. While studying how genotoxic stress kills …
is essential to improve combination therapies. While studying how genotoxic stress kills …
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
O Micheau, J Tschopp - Cell, 2003 - cell.com
Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …
Signaling to NF-κB
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …
decades. Over this period, considerable progress has been made in determining the …
Intracellular regulation of TNF activity in health and disease
E Varfolomeev, D Vucic - Cytokine, 2018 - Elsevier
Abstract Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of
mammalian immune responses in healthy organisms and in diseased conditions. TNF …
mammalian immune responses in healthy organisms and in diseased conditions. TNF …
Lipid rafts in immune signalling: current progress and future perspective
Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and
regulatory molecules and so act as a platform for signal transduction. They float freely within …
regulatory molecules and so act as a platform for signal transduction. They float freely within …
The lipid basis of cell death and autophagy
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …
biological functions. These lipids act as vital structural components of cell membranes …