Regulation of tumour necrosis factor signalling: live or let die

D Brenner, H Blaser, TW Mak - Nature Reviews Immunology, 2015 - nature.com
Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in
mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) …

Signalling pathways of the TNF superfamily: a double-edged sword

BB Aggarwal - Nature reviews immunology, 2003 - nature.com
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be
cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past …

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

J Zhang, B Zhou, R Sun, Y Ai, K Cheng, F Li, B Wang… - Cell research, 2021 - nature.com
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among
which the function of GSDMC has not been clearly described. Herein, we demonstrate that …

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

X Chen, W Li, J Ren, D Huang, W He, Y Song, C Yang… - Cell research, 2014 - nature.com
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …

[HTML][HTML] The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

T Tenev, K Bianchi, M Darding, M Broemer, C Langlais… - Molecular cell, 2011 - cell.com
A better understanding of the mechanisms through which anticancer drugs exert their effects
is essential to improve combination therapies. While studying how genotoxic stress kills …

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

O Micheau, J Tschopp - Cell, 2003 - cell.com
Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …

Signaling to NF-κB

MS Hayden, S Ghosh - Genes & development, 2004 - genesdev.cshlp.org
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

Intracellular regulation of TNF activity in health and disease

E Varfolomeev, D Vucic - Cytokine, 2018 - Elsevier
Abstract Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of
mammalian immune responses in healthy organisms and in diseased conditions. TNF …

Lipid rafts in immune signalling: current progress and future perspective

P Varshney, V Yadav, N Saini - Immunology, 2016 - Wiley Online Library
Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and
regulatory molecules and so act as a platform for signal transduction. They float freely within …

The lipid basis of cell death and autophagy

Z Lin, F Long, R Kang, DJ Klionsky, M Yang, D Tang - Autophagy, 2024 - Taylor & Francis
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …