Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

Background A novel multicomponent vaccine against meningococcal capsular group B
(MenB) disease contains four major components: factor-H-binding protein, neisserial …

A unique multicomponent vaccine against serogroup B meningococci incorporates the novel
genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence and level of …

Clin Microbiol Infect 2012; 18 (Suppl. 5): 109–116 Abstract Vaccines have a significant
impact on public health, and vaccinology in the era of genomics is taking advantage of new …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

DNA tandem repeats (TRs), also designated as satellite DNA, are inter-or intragenic
nucleotide sequences that are repeated two or more times in a head-to-tail manner …

Phase variation yields phenotypic heterogeneity in a clonal population as the result of one of
a limited number of known molecular mechanisms. These include slipped strand mispairing …

Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been
the major focus of most large-scale comparative genomics studies to date. Here, we discuss …

During infection Neisseria meningitidis (Nm) encounters multiple environments within the
host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the …