Cytogenetics and molecular cytogenetics are and will continue to be indispensable tools in
cancer diagnostics. Leukemia and lymphoma diagnostics are still emphases of routine …

Identifying additional genetic alterations associated with poor prognosis in acute
lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of …

MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene
expression at posttranscriptional level. Here, we identified that miR-590 and its predicted …

Abstract Deletions within chromosome 11q22‑23, are considered among the most common
chromosomal aberrations in chronic lymphocytic leukemia (CLL), and are associated with a …

Acute lymphoblastic leukemia (ALL) accounts for 20% of all adult leukemias and is the most
common leukemia during childhood (80%). We present data on cytogenetics of ALL from a …

MLL (mixed-lineage-leukemia) gene rearrangements are typical for acute leukemia and are
associated with an aggressive course of disease, with a worse outcome than comparable …

Highlights•The t (3; 7)(q26; q21) juxtaposes MECOM and CDK6 genes. MECOM disruption
affects cell differentiation and proliferation.•MECOM overexpression is associated with …

In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may
help to estimate prognosis. However, deletion of TP53 gene, which is associated with an …

Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have
a dismal outcome. However, for patients with a KMT2A rearrangement (KMT2A-r), the …

A malignus onkohematológiai kórképek kutatása és diagnosztikája számos alkalommal járt
élen a daganatos betegségek hátterében meghúzódó genetikai folyamatok felderítésében …