Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer
(NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is …

Recently, the use of chimeric antigen receptor-modified T (CAR-T)-cells in the treatment of
hematological tumors has been successful and has become a clinical hotspot in tumor …

Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the
field of cellular therapy for cancer. Despite its success, this strategy has some recognised …

In contrast to donor T cells, natural killer (NK) cells are known to mediate anti-cancer effects
without the risk of inducing graft-versus-host disease (GvHD). In order to improve cytotoxicity …