The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

The cellular complexity of human brain development has been intensively investigated,
although a regional characterization of the entire human cerebral cortex based on single …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …

Mutations in FOXP1 have been linked to neurodevelopmental disorders including
intellectual disability and autism; however, the underlying molecular mechanisms remain ill …

The striatum is a critical forebrain structure integrating cognitive, sensory, and motor
information from diverse brain regions into meaningful behavioral output. However, the …

Genetic perturbations of the transcription factor Forkhead Box P1 (FOXP1) are causative for
severe forms of autism spectrum disorder that are often comorbid with intellectual disability …

The amygdala is a hyperspecialized brain region composed of strongly inter-and
intraconnected nuclei involved in emotional learning and behavior. The cellular …

The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory
components of amygdalar circuits, which control appropriate fear responses. Despite this …

Genetic mutations of FOXP1 and FOXP2 are associated with neurodevelopmental diseases.
It is important to characterize the cell types that express Foxp1 and Foxp2 in the brain. Foxp1 …