Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling
platforms that drive cellular transformation upon integrin-dependent adhesion and growth …

Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …

One of the hallmarks of cancers is the silencing of tumour suppressor genes and pathways.
The Hippo tumour suppressor pathway is inactivated in many types of cancers, leading to …

Activating KRAS mutations are found in over 90% of pancreatic ductal adenocarcinomas
(PDACs), yet KRAS has remained a difficult target to inhibit pharmacologically. Here, we …

Big data bring new opportunities for methods that efficiently summarize and automatically
extract knowledge from such compendia. While both supervised learning algorithms and …

In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …

The first description of cancer is found in an Egyptian papyrus and dates back to
approximately 1600 BC. It was regarded as an incurable disease until the nineteenth …

An unbiased proteomic screen to identify integrin-linked kinase (ILK) interactors revealed
rictor as an ILK-binding protein. This finding was interesting because rictor, originally …

Epithelial-to-mesenchymal transition (EMT) causes fibrosis, cancer progression and
metastasis. Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine …

Integrin-linked kinase (ILK) directly interacts with β integrins and phosphorylates Akt in a
phosphatidylinositol 3-kinase (PI3K)–dependent manner. In this study, we examined the …