The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Regeneration of injured neurons can restore function, but most neurons regenerate poorly
or not at all. The failure to regenerate in some cases is due to a lack of activation of cell …

The ability to sense and respond to mechanical stimuli emanates from sensory neurons and
is shared by most, if not all, animals. Exactly how such neurons receive and distribute …

Axons and dendrites can withstand acute mechanical strain despite their small diameter. In
this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal …

The morphogenesis of the C. elegans embryo is largely controlled by the development of the
epidermis, also known as the hypodermis, a single epithelial layer that surrounds the …

Our bodies are in constant motion and so are the neurons that invade each tissue. Motion-
induced neuron deformation and damage are associated with several neurodegenerative …

Background Mutations that cause feeding defects in the nematode C. elegans are known to
increase life span. Here we show that feeding defective mutants also have a second general …