The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls
the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2, 3, 7, 8 …

Fields such as genomics and systems biology are built on the synergism between
computational and experimental techniques. This type of synergism is especially important …

Lag phase represents the earliest and most poorly understood stage of the bacterial growth
cycle. We developed a reproducible experimental system and conducted functional genomic …

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether
changes in chromatin states in the parental generation could be incompletely …

Summary G-quadruplex (G4) DNA structures are extremely stable four-stranded secondary
structures held together by noncanonical GG base pairs. Genome-wide chromatin …

DNA segments that actively regulate transcription in vivo are typically characterized by
eviction of nucleosomes from chromatin and are experimentally identified by their …

Tissue-specific transcriptional regulation is central to human disease. To identify regulatory
DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted …

Eviction or destabilization of nucleosomes from chromatin is a hallmark of functional
regulatory elements in eukaryotic genomes. Historically identified by nuclease …

Eukaryotic chromatin is separated into functional domains differentiated by post-translational
histone modifications, histone variants and DNA methylation,,,,,. Methylation is associated …

Next-generation DNA sequencing coupled with chromatin immunoprecipitation (ChIP-seq)
is revolutionizing our ability to interrogate whole genome protein-DNA interactions …