Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
[HTML][HTML] A transcription factor atlas of directed differentiation
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …
processes and cell states. To comprehensively understand TFs and the programs they …
Temporal modelling using single-cell transcriptomics
J Ding, N Sharon, Z Bar-Joseph - Nature Reviews Genetics, 2022 - nature.com
Methods for profiling genes at the single-cell level have revolutionized our ability to study
several biological processes and systems including development, differentiation, response …
several biological processes and systems including development, differentiation, response …
Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
Multiscale and integrative single-cell Hi-C analysis with Higashi
Abstract Single-cell Hi-C (scHi-C) can identify cell-to-cell variability of three-dimensional
(3D) chromatin organization, but the sparseness of measured interactions poses an analysis …
(3D) chromatin organization, but the sparseness of measured interactions poses an analysis …
Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE
J He, IA Babarinde, L Sun, S Xu, R Chen, J Shi… - Nature …, 2021 - nature.com
Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
[HTML][HTML] Modeling human multi-lineage heart field development with pluripotent stem cells
The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …