[HTML][HTML] Synthesis of biologically active molecules through multicomponent reactions
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …
significant role that multicomponent reactions (MCRs) have played as a very important tool …
Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …
incremental scientific work and all positive socio-political engagements, are steps taken in …
[HTML][HTML] Tuberculosis drug discovery: A decade of hit assessment for defined targets
More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis
SJ Tantry, SD Markad, V Shinde, J Bhat… - Journal of medicinal …, 2017 - ACS Publications
The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate
(ATP) synthase as an attractive target to kill Mycobacterium tuberculosis (Mtb). Herein, we …
(ATP) synthase as an attractive target to kill Mycobacterium tuberculosis (Mtb). Herein, we …
Design, synthesis, and biological evaluation of benzo [d] imidazole-2-carboxamides as new anti-TB agents
TM Dhameliya, KI Patel, R Tiwari, SK Vagolu… - Bioorganic …, 2021 - Elsevier
Tuberculosis is the leading cause of death globally among infectious diseases. Due to the
development of resistance of Mycobacterium tuberculosis to currently used anti-TB …
development of resistance of Mycobacterium tuberculosis to currently used anti-TB …
[HTML][HTML] Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis
New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …
Discovery and optimization of novel biphenyl derivatives bearing cyclopropyl linkage as potent programmed cell death-1/programmed cell death-ligand 1 inhibitors
T Jing, Z Zhang, Z Kang, J Mo, X Yue… - Journal of Medicinal …, 2023 - ACS Publications
A series of novel compounds bearing a cyclopropyl linkage were designed, synthesized,
and evaluated as programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) …
and evaluated as programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) …
Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
In this study, a new series of benzimidazole and bisbenzimidazole derivatives were
prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then …
prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then …
Synthesis and molecular docking study of some 5, 6-dichloro-2-cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as …
A new series of benzimidazole compounds including hydrazinecarbothioamide, 1, 2, 4-
triazole, 1, 3, 4-oxadiazole and imine function were synthesized starting from 5, 6-dichloro-2 …
triazole, 1, 3, 4-oxadiazole and imine function were synthesized starting from 5, 6-dichloro-2 …