Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

M Agrawal, DK Tripathi, S Saraf, S Saraf… - Journal of controlled …, 2017 - Elsevier
In this modern era, with the help of various advanced technologies, medical science has
overcome most of the health-related issues successfully. Though, some diseases still remain …

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization

IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

[HTML][HTML] A molecular approach in drug development for Alzheimer's disease

S Agatonovic-Kustrin, C Kettle, DW Morton - Biomedicine & …, 2018 - Elsevier
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

F Zemek, L Drtinova, E Nepovimova… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a world-wide health problem with implications for
an increasing number of people and countries. Populations suffering from AD financially …

Plant alkaloids as drug leads for Alzheimer's disease

YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …

Potential therapeutic applications of plant‐derived alkaloids against inflammatory and neurodegenerative diseases

B Aryal, BK Raut, S Bhattarai… - Evidence‐Based …, 2022 - Wiley Online Library
Alkaloids are a type of natural compound possessing different pharmacological activities.
Natural products, including alkaloids, which originate from plants, have emerged as …

The role of phytochemicals in the treatment and prevention of dementia

MJR Howes, E Perry - Drugs & aging, 2011 - Springer
Dementia pathologies such as Alzheimer's disease (AD) are reaching epidemic proportions,
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …

Does kynurenic acid act on nicotinic receptors? An assessment of the evidence

TW Stone - Journal of neurochemistry, 2020 - Wiley Online Library
As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic
acid is of considerable biological and clinical importance as an endogenous antagonist of …

[HTML][HTML] Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease

S Bhattacharya, C Haertel, A Maelicke, D Montag - PloS one, 2014 - journals.plos.org
The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer's
disease (AD), providing temporary cognitive and global relief in human patients. In this …