Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease
In this modern era, with the help of various advanced technologies, medical science has
overcome most of the health-related issues successfully. Though, some diseases still remain …
overcome most of the health-related issues successfully. Though, some diseases still remain …
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
[HTML][HTML] A molecular approach in drug development for Alzheimer's disease
S Agatonovic-Kustrin, C Kettle, DW Morton - Biomedicine & …, 2018 - Elsevier
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …
prompts the need for new medications to treat the complex biological dysfunctions, such as …
Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
F Zemek, L Drtinova, E Nepovimova… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a world-wide health problem with implications for
an increasing number of people and countries. Populations suffering from AD financially …
an increasing number of people and countries. Populations suffering from AD financially …
Plant alkaloids as drug leads for Alzheimer's disease
YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …
most prevalent among the elderly population. Current medications can only treat symptoms …
Potential therapeutic applications of plant‐derived alkaloids against inflammatory and neurodegenerative diseases
Alkaloids are a type of natural compound possessing different pharmacological activities.
Natural products, including alkaloids, which originate from plants, have emerged as …
Natural products, including alkaloids, which originate from plants, have emerged as …
The role of phytochemicals in the treatment and prevention of dementia
MJR Howes, E Perry - Drugs & aging, 2011 - Springer
Dementia pathologies such as Alzheimer's disease (AD) are reaching epidemic proportions,
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …
Does kynurenic acid act on nicotinic receptors? An assessment of the evidence
TW Stone - Journal of neurochemistry, 2020 - Wiley Online Library
As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic
acid is of considerable biological and clinical importance as an endogenous antagonist of …
acid is of considerable biological and clinical importance as an endogenous antagonist of …
[HTML][HTML] Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease
S Bhattacharya, C Haertel, A Maelicke, D Montag - PloS one, 2014 - journals.plos.org
The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer's
disease (AD), providing temporary cognitive and global relief in human patients. In this …
disease (AD), providing temporary cognitive and global relief in human patients. In this …