[HTML][HTML] Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
[HTML][HTML] Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …
What is cancer metabolism?
LWS Finley - Cell, 2023 - cell.com
The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …
bioenergetics to biomass production and cell fate regulation. While many studies of cell …
[HTML][HTML] Uridine-derived ribose fuels glucose-restricted pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to
therapy,. This is mediated in part by a complex tumour microenvironment, low vascularity …
therapy,. This is mediated in part by a complex tumour microenvironment, low vascularity …
[HTML][HTML] Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
T Zhang, Y Ren, P Yang, J Wang, H Zhou - Cell Death & Disease, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …
[HTML][HTML] The hexosamine biosynthesis pathway: regulation and function
A Paneque, H Fortus, J Zheng, G Werlen, E Jacinto - Genes, 2023 - mdpi.com
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
Epithelial and stromal co-evolution and complicity in pancreatic cancer
SR Hingorani - Nature Reviews Cancer, 2023 - nature.com
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
[HTML][HTML] Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors
A Vaziri-Gohar, J Cassel, FS Mohammed, M Zarei… - Nature Cancer, 2022 - nature.com
Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell
viability due to increased free radicals and reduced energy production. In pancreatic cancer …
viability due to increased free radicals and reduced energy production. In pancreatic cancer …
[HTML][HTML] Biofabrication methods for reconstructing extracellular matrix mimetics
A Aazmi, D Zhang, C Mazzaglia, M Yu, Z Wang… - Bioactive Materials, 2024 - Elsevier
In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …
tissue and organ-specific compositions and architectures. These ECMs not only function as …
The biological underpinnings of therapeutic resistance in pancreatic cancer
GL Beatty, G Werba, CA Lyssiotis… - Genes & …, 2021 - genesdev.cshlp.org
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal …
the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal …