Investigation of the toxicity triggered by chemicals on the human brain has traditionally relied
on approaches using rodent in vivo models and in vitro cell models including primary …

Mitochondria are essential organelles for cellular integrity and functionality maintenance
and their imparement is implicated in the development of a wide range of diseases …

Recent studies have revealed robust metabolic changes during cell differentiation.
Mitochondria, the organelles where many vital metabolic reactions occur, may play an …

Mitochondrial respiration is a crucial component of cellular metabolism that can become
dysregulated in cancer. Compared with normal hematopoietic cells, acute myeloid leukemia …

The immortalized and proliferative cell line SH-SY5Y is one of the most commonly used cell
lines in neuroscience and neuroblastoma research. However, undifferentiated SH-SY5Y …

Introduction Neuroblastoma is a malignant pediatric cancer derived from neural crest cells. It
is characterized by a generalized reduction of mitochondrial oxidative phosphorylation. The …

Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, is associated with
neuroinflammation. Periodontal disease increases with age; 70.1% of adults 65 years and …

Cadmium (Cd), a worldwide occupational pollutant, is an extremely toxic heavy metal,
capable of damaging several organs, including the brain. Its toxicity has been related to …

Brain development requires a fine-tuned copper homoeostasis. Copper deficiency or excess
results in severe neuro-pathologies. We demonstrate that upon neuronal differentiation …

RAGE is a multiligand receptor able to bind advanced glycation end‐products (AGEs),
amphoterin, calgranulins, and amyloid‐beta peptides, identified in many tissues and cells …