Over the past decades, adoptive transfer of T cells has revolutionized cancer
immunotherapy. In particular, T-cell receptor (TCR) engineering of T cells has marked …

Analysis of antigen‐specific T‐cell populations by flow cytometry with peptide–MHC (pMHC)
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …

The forces that govern clonal selection during the genesis and maintenance of specific T cell
responses are complex, but amenable to decryption by interrogation of constituent …

Cell-based antitumor immunity is driven by CD8+ cytotoxic T cells bearing TCR that
recognize specific tumor-associated peptides bound to class I MHC molecules. Of several …

Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute
myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the …

T cells have evolved a unique system of ligand recognition involving an antigen T cell
receptor (TCR) and a coreceptor that integrate stimuli provided by the engagement of …

The development of fluorochrome‐conjugated peptide–major histocompatibility complex
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …

Assessment of clonal diversity of T cell responses against human CMV (HCMV), a major
cause of morbidity in immunodepressed patients, provides important insights into the …

While proteins are critical for immunity, T-cells constitute a critical component of adaptive
immunity by clearing cancerous cells among other abnormal cells. However, cancer cells …

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …