Drug-repositioning approaches based on medical and life science databases
Y Zamami, H Hamano, T Niimura, F Aizawa… - Frontiers in …, 2021 - frontiersin.org
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a
therapeutic agent for a different disease. As information regarding the safety …
therapeutic agent for a different disease. As information regarding the safety …
DruMAP: A novel drug metabolism and pharmacokinetics analysis platform
H Kawashima, R Watanabe, T Esaki… - Journal of Medicinal …, 2023 - ACS Publications
We developed a novel drug metabolism and pharmacokinetics (DMPK) analysis platform
named DruMAP. This platform consists of a database for DMPK parameters and programs …
named DruMAP. This platform consists of a database for DMPK parameters and programs …
Deep learning prediction of adverse drug reactions in drug discovery using open TG–GATEs and FAERS databases
Machine learning techniques are being increasingly used in the analysis of clinical and
omics data. This increase is primarily due to the advancements in Artificial intelligence (AI) …
omics data. This increase is primarily due to the advancements in Artificial intelligence (AI) …
Identification of hub pathways and drug candidates in gastric cancer through systems biology
SR Salarikia, M Kashkooli, MJ Taghipour… - Scientific Reports, 2022 - nature.com
Gastric cancer is the fourth cause of cancer death globally, and gastric adenocarcinoma is
its most common type. Efforts for the treatment of gastric cancer have increased its median …
its most common type. Efforts for the treatment of gastric cancer have increased its median …
Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity
V Girard, V Goubard, M Querenet, L Seugnet, L Pays… - Scientific Reports, 2020 - nature.com
Glial cells are early sensors of neuronal injury and can store lipids in lipid droplets under
oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein …
oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein …
Mass spectrometry-based proteomic exploration of the small urinary extracellular vesicles in ANCA-associated vasculitis in comparison with total urine
P Prikryl, V Satrapova, J Frydlova, Z Hruskova… - Journal of …, 2021 - Elsevier
ANCA-associated vasculitis (AAV) is a rare, but potentially severe autoimmune disease,
even nowadays displaying increased mortality and morbidity. Finding early biomarkers of …
even nowadays displaying increased mortality and morbidity. Finding early biomarkers of …
TGFB1-mediated gliosis in multiple sclerosis spinal cords is favored by the regionalized expression of HOXA5 and the age-dependent decline in androgen receptor …
S Nataf, M Guillen, L Pays - International Journal of Molecular Sciences, 2019 - mdpi.com
In multiple sclerosis (MS) patients with a progressive form of the disease, spinal cord (SC)
functions slowly deteriorate beyond age 40. We previously showed that in the SC of these …
functions slowly deteriorate beyond age 40. We previously showed that in the SC of these …
Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets
Abstract Corona virus disease 2019 (COVID-19) increases the risk of cardiovascular
occlusive/thrombotic events and is linked to poor outcomes. The underlying …
occlusive/thrombotic events and is linked to poor outcomes. The underlying …
Integrative network modeling highlights the crucial roles of rho-GDI signaling pathway in the progression of non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and a leading
cause of cancer-related deaths worldwide. Using an integrative approach, we analyzed a …
cause of cancer-related deaths worldwide. Using an integrative approach, we analyzed a …
QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism
K Hosomi, N Hatanaka, A Hinenoya, J Adachi… - Frontiers in …, 2024 - frontiersin.org
Introduction Campylobacter spp. are a public health concern, yet there is still no effective
vaccine or medicine available. Methods Here, we developed a Campylobacter jejuni …
vaccine or medicine available. Methods Here, we developed a Campylobacter jejuni …