Drug-repositioning approaches based on medical and life science databases

Y Zamami, H Hamano, T Niimura, F Aizawa… - Frontiers in …, 2021 - frontiersin.org
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a
therapeutic agent for a different disease. As information regarding the safety …

DruMAP: A novel drug metabolism and pharmacokinetics analysis platform

H Kawashima, R Watanabe, T Esaki… - Journal of Medicinal …, 2023 - ACS Publications
We developed a novel drug metabolism and pharmacokinetics (DMPK) analysis platform
named DruMAP. This platform consists of a database for DMPK parameters and programs …

Deep learning prediction of adverse drug reactions in drug discovery using open TG–GATEs and FAERS databases

A Mohsen, LP Tripathi, K Mizuguchi - Frontiers in Drug Discovery, 2021 - frontiersin.org
Machine learning techniques are being increasingly used in the analysis of clinical and
omics data. This increase is primarily due to the advancements in Artificial intelligence (AI) …

Identification of hub pathways and drug candidates in gastric cancer through systems biology

SR Salarikia, M Kashkooli, MJ Taghipour… - Scientific Reports, 2022 - nature.com
Gastric cancer is the fourth cause of cancer death globally, and gastric adenocarcinoma is
its most common type. Efforts for the treatment of gastric cancer have increased its median …

Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

V Girard, V Goubard, M Querenet, L Seugnet, L Pays… - Scientific Reports, 2020 - nature.com
Glial cells are early sensors of neuronal injury and can store lipids in lipid droplets under
oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein …

Mass spectrometry-based proteomic exploration of the small urinary extracellular vesicles in ANCA-associated vasculitis in comparison with total urine

P Prikryl, V Satrapova, J Frydlova, Z Hruskova… - Journal of …, 2021 - Elsevier
ANCA-associated vasculitis (AAV) is a rare, but potentially severe autoimmune disease,
even nowadays displaying increased mortality and morbidity. Finding early biomarkers of …

TGFB1-mediated gliosis in multiple sclerosis spinal cords is favored by the regionalized expression of HOXA5 and the age-dependent decline in androgen receptor …

S Nataf, M Guillen, L Pays - International Journal of Molecular Sciences, 2019 - mdpi.com
In multiple sclerosis (MS) patients with a progressive form of the disease, spinal cord (SC)
functions slowly deteriorate beyond age 40. We previously showed that in the SC of these …

Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets

AB Alarabi, A Mohsen, K Mizuguchi, FZ Alshbool… - BMC Medical …, 2022 - Springer
Abstract Corona virus disease 2019 (COVID-19) increases the risk of cardiovascular
occlusive/thrombotic events and is linked to poor outcomes. The underlying …

Integrative network modeling highlights the crucial roles of rho-GDI signaling pathway in the progression of non-small cell lung cancer

S Gupta, H Vundavilli, RSA Osorio… - IEEE Journal of …, 2022 - ieeexplore.ieee.org
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and a leading
cause of cancer-related deaths worldwide. Using an integrative approach, we analyzed a …

QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism

K Hosomi, N Hatanaka, A Hinenoya, J Adachi… - Frontiers in …, 2024 - frontiersin.org
Introduction Campylobacter spp. are a public health concern, yet there is still no effective
vaccine or medicine available. Methods Here, we developed a Campylobacter jejuni …