Fluorescence microscopy is a key driver of discoveries in the life sciences, with observable
phenomena being limited by the optics of the microscope, the chemistry of the fluorophores …

How tissue shape emerges from the collective mechanical properties and behavior of
individual cells is not understood. We combine experiment and theory to study this problem …

Planar cell polarity (PCP) proteins form polarized cortical domains that govern polarity of
external structures such as hairs and cilia in both vertebrate and invertebrate epithelia. The …

Understanding the mechanisms regulating development requires a quantitative
characterization of cell divisions, rearrangements, cell size and shape changes, and …

The establishment and maintenance of polarized plasma membrane domains is essential
for cellular function and proper development of organisms. Epithelial cells polarize along …

Studying how epithelia respond to mechanical stresses is key to understanding tissue shape
changes during morphogenesis. Here, we study the viscoelastic properties of the Drosophila …

Planar cell rearrangements control epithelial tissue morphogenesis and cellular pattern
formation. They lead to the formation of new junctions whose length and stability determine …

The core planar polarity proteins localize asymmetrically to the adherens junctions of
epithelial cells, where they have been hypothesized to assemble into intercellular …

Comprehensive analysis of cellular dynamics during the process of morphogenesis is
fundamental to understanding the principles of animal development. Despite recent …

The control of organ size mainly relies on precise autonomous growth programs. However,
organ development is subject to random variations, called developmental noise, best …