Mass spectrometry-based metabolomics in microbiome investigations
A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …
[HTML][HTML] Streptomyces: The biofactory of secondary metabolites
Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …
[HTML][HTML] Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective
There is a real consensus that new antibiotics are urgently needed and are the best chance
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …
Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery
GA Quinn, AM Banat… - Journal of medical …, 2020 - microbiologyresearch.org
Given the increased reporting of multi-resistant bacteria and the shortage of newly approved
medicines, researchers have been looking towards extreme and unusual environments as a …
medicines, researchers have been looking towards extreme and unusual environments as a …
[HTML][HTML] Actinobacteria in natural products research: Progress and prospects
Actinobacteria are well-recognised biosynthetic factories that produce an extensive
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …
spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation …
A marine microbiome antifungal targets urgent-threat drug-resistant fungi
New antifungal drugs are urgently needed to address the emergence and transcontinental
spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging …
spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging …
Diversity and functional landscapes in the microbiota of animals in the wild
D Levin, N Raab, Y Pinto, D Rothschild, G Zanir… - Science, 2021 - science.org
Animals in the wild are able to subsist on pathogen-infected and poisonous food and show
immunity to various diseases. These may be due to their microbiota, yet we have a poor …
immunity to various diseases. These may be due to their microbiota, yet we have a poor …
[HTML][HTML] A roadmap for metagenomic enzyme discovery
SL Robinson, J Piel, S Sunagawa - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …