Traditionally, γ-aminobutyric acid (GABA) is best known for its role as a primary inhibitory
neurotransmitter reducing neuronal excitability in the mammalian central nervous system …

Metabolomics represents a global quantitative assessment of metabolites within a biological
system. The metabolic analysis of cell cultures has many potential applications and …

Germline mutations in the BRCA2 tumour suppressor are associated with both an increased
lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease …

Maternal obesity and overnutrition during pregnancy and lactation can program an
increased risk of obesity in offspring. In this context, improving maternal metabolism may …

GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

Since its introduction in the 1970s, the field of metabolic NMR has made several milestones
of advances, first in the in vivo application of cell suspensions and excised tissues (most …

Aside from traditional neurotransmission and regulation of secretion, γ-amino butyric acid
(GABA) through GABAA receptors negatively regulates proliferation of pluripotent and …

Transient receptor potential canonical 1 (TRPC1), a widely expressed calcium (Ca2+)-
permeable channel, is potentially involved in the pathogenesis of Duchenne muscular …

Background Resistance to modern adjuvant treatment is in part due to the failure of
programmed cell death. Therefore the molecules that execute the apoptotic program are …

Background The biomarker identification of human esophageal cancer is critical for its early
diagnosis and therapeutic approaches that will significantly improve patient survival …