[HTML][HTML] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
MJ Simon, T Logan, SL DeVos, G Di Paolo - Trends in Cell Biology, 2023 - cell.com
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
[HTML][HTML] Progranulin as a therapeutic target in neurodegenerative diseases
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …
[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
[HTML][HTML] Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
J García-Revilla, A Boza-Serrano… - Cell death & …, 2022 - nature.com
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed
different phenotypes that are inherently associated with disease conditions. A common …
different phenotypes that are inherently associated with disease conditions. A common …
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
A Reifschneider, S Robinson, B van Lengerich… - The EMBO …, 2022 - embopress.org
Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
[HTML][HTML] Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic …
N Huber, S Korhonen, D Hoffmann, S Leskelä… - Molecular …, 2022 - nature.com
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
Elevated galectin-3 is associated with aging, multiple sclerosis, and oxidized phosphatidylcholine-induced neurodegeneration
S Xue, BM Lozinski, S Ghorbani, K Ta… - Journal of …, 2023 - Soc Neuroscience
Aging is a significant risk factor associated with the progression of CNS neurodegenerative
diseases including multiple sclerosis (MS). Microglia, the resident macrophages of the CNS …
diseases including multiple sclerosis (MS). Microglia, the resident macrophages of the CNS …
[HTML][HTML] TDP-43 and inflammation: implications for amyotrophic lateral sclerosis and frontotemporal dementia
The abnormal mislocalisation and ubiquitinated protein aggregation of the TAR DNA
binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous …
binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous …
[HTML][HTML] Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system
Introduction Progranulin (PGRN) is a secreted glycoprotein, the expression of which is
linked to several neurodegenerative diseases. Although its specific function is still unclear …
linked to several neurodegenerative diseases. Although its specific function is still unclear …
Innate immune activation in neurodegenerative diseases
S Castro-Gomez, MT Heneka - Immunity, 2024 - cell.com
Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …