Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Multiple large-scale restoration strategies are emerging globally to counteract ecosystem
degradation and biodiversity loss. However, restoration often remains insufficient to offset …

Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering
dissection of COVID-19 biology. We use comparative genomics to provide a high …

Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …

The comparison of related genomes has emerged as a powerful lens for genome
interpretation. Here we report the sequencing and comparative analysis of 29 eutherian …

Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

Genomes contain both a genetic code specifying amino acids and a regulatory code
specifying transcription factor (TF) recognition sequences. We used genomic …

Genomics promises exciting advances towards the important conservation goal of
maximizing evolutionary potential, notwithstanding associated challenges. Here, we explore …

Messenger RNA is a key component of an intricate regulatory network of its own. It
accommodates numerous nucleotide signals that overlap protein coding sequences and are …

Enhancers are essential gene regulatory elements whose alteration can lead to
morphological differences between species, developmental abnormalities, and human …