Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …

Thiyl radicals have been used by nature in a broad range of biochemical processes. For
instance, thiol residues play an important role in many enzymatic processes as illustrated by …

Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …

Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Glutathione (GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological …

Abstract Significance: The thioredoxin (Trx) system, comprising nicotinamide adenine
dinucleotide phosphate, Trx reductase (TrxR), and Trx, is critical for maintaining cellular …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …