Identification and treatment of latent tuberculosis infection (LTBI) can substantially reduce
the risk of developing active disease. However, there is no diagnostic gold standard for LTBI …

Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent
infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for …

Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Despite achieving great public health strides to control tuberculosis (TB) within the United
States, it remains an enormous public health issue worldwide. Accurate statistics on …

Early clearance (EC) is the successful eradication of inhaled M ycobacterium tuberculosis
before an adaptive immune response develops. Evidence for EC comes from case contact …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is currently the
deadliest infectious disease in human that can evolve to severe forms. A comprehensive …

Diagnosis represents only one aspect of tuberculosis (TB) control but is perhaps one of the
most challenging. The drawbacks of current tools highlight several unmet needs in TB …

The identification of individuals with latent tuberculosis infection (LTBI) is useful for both
fundamental understanding of the pathogenesis of disease and for clinical and public health …

Significance: High-mobility group protein box 1 (HMGB1), a ubiquitous nuclear protein,
regulates chromatin structure and modulates the expression of many genes involved in the …

Effective prophylactic and/or therapeutic vaccination is a key strategy for controlling the
global TB epidemic. The partial effectiveness of the existing TB vaccine, bacille Calmette …