m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
occurrence, development, progression and prognosis of cancer, and aberrant m6A …
Role of m6A writers, erasers and readers in cancer
Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 …
Q Li, Y Ni, L Zhang, R Jiang, J Xu, H Yang… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …
Mapping the genomic diaspora of gastric cancer
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S Hüttelmaier… - Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A …
Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation
W Lin, L Chen, H Zhang, X Qiu, Q Huang… - Nature …, 2023 - nature.com
The recently described role of RNA methylation in regulating immune cell infiltration into
tumors has attracted interest, given its potential impact on immunotherapy response …
tumors has attracted interest, given its potential impact on immunotherapy response …
YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance
Y Sun, D Dong, Y Xia, L Hao, W Wang, C Zhao - Cell Death & Disease, 2022 - nature.com
Chemoresistance represents a major obstacle to the treatment of human cancers. Increased
DNA repair capacity is one of the important mechanisms underlying chemoresistance. In …
DNA repair capacity is one of the important mechanisms underlying chemoresistance. In …
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
m6A Reader YTHDF1‐Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation
Q You, F Wang, R Du, J Pi, H Wang, Y Huo… - Advanced …, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) modulators decide the fate of m6A‐modified transcripts
and drive cancer development. RNA interference targeting m6A modulators promise to be …
and drive cancer development. RNA interference targeting m6A modulators promise to be …
Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …
(TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6 …